Advances in Immunology, Vol. 61 by Frank J. Dixon

By Frank J. Dixon

"The sequence which all immunologists need." --The Pharmaceutical magazine "Advances in Immunology needs to locate itself one of the so much lively volumes within the libraries of our universities and institutions." --Science "Deserves an enduring position in biomedical libraries as an relief in study and in instructing" --Journal of Immunological equipment "A provocative and scholarly overview of analysis" --Journal of the yankee scientific organization "Provides an incredibly helpful resource of reference and plenty of stimulating ideas...the major repository of data in a quickly devloping topic" --The Lancet "Provides unrivalled price in either educational and monetary phrases and may be bought by way of tough pressed librarians as an incredible precedence to be jealously defended." --Journal of clinical Microbiology "A very worthy serial critical scholar of immunology can have enough money to be with no it." --Archives of Biochemistry and Biophysics Key gains * specialize in parts of the V(D)J recombination equipment that will be regarding ailments in people and animals * regulate of the supplement approach by means of regulate of C3/C5 convertase on host cells, keep watch over of fluid part C3/C5 convertases, keep an eye on of fluid part MAC, and keep an eye on of deposited MAC * Immunodeficiency because of an entire absence of MHC category II expression and trans-acting elements controlling transcription * present wisdom of IL-2R signaling, highlighting IL-2 signaling, and T-cell progress law * sensible function of CD40 in cells, the in vivo value of CD40-CD40-L interactions, and the sign transduction equipment activated following crosslinking of the CD40 antigen * Integrative method of larger comprehend the saw heterogeneity of someone reaction to allergens * rules of isotype specificity, swap recombination rules, and the mechanism of switching * lymphocyte-specific proteins, RAG1 and RAG2, begin V(D)J recombination of antigen receptor genes

Show description

Read Online or Download Advances in Immunology, Vol. 61 PDF

Similar scientific-popular books

Science and Society in the Face of the New Security Threats

This feature of papers explores the demanding situations confronted by means of the technology institutions within the new safety surroundings throughout more than a few NATO international locations, and examines attainable suggestions via taking a look in nearer element at a few nationwide case stories. It units out the significance of the NATO protection via technological know-how programme within the new safety setting.

What Does the World Want from America? International Perspectives on U.S. Foreign Policy (Washington Quarterly Readers)

The us is the single superpower on this planet at the present time. even if the media are choked with prescriptions for a way Washington may possibly most sensible wield its energy, hardly ever are different nations requested what position they want the us to play. In What Does the realm wish from the US?

The News Shapers: The Sources Who Explain the News

This quantity describes and analyzes the elite membership of people that the media strategy for "inside information," heritage, or predictions about the consequence of still-unfolding tales. in keeping with a examine analyzing 3 significant networks' night newscasts in the course of 1987-1988, it unearths small variety of white, politically conservative males linked to Washington-based imagine tanks, former Republican administrations, and personal East Coast universities nearly monopolize political discourse within the mass media.

Additional resources for Advances in Immunology, Vol. 61

Sample text

Again using the two hybrid system, Fas was demonstrated to associate with several proteins. , 1995). Overexpression of this protein renders cells resistant to Fas-induced apoptosis, and cells that spontaneously express high levels of FAP-1 consistently are relatively resistant to Fas-mediated apoptosis. FAP-1 binds to the 15 carboxy-terminal AA of Fas, a region which has been demonstrated to be a negative regulator of Fas activity, because apoptosis increases after deletion of this fragment (Itoh and Nagata, 1993).

Gel retardation assays showed the presence of, at least, the NF-kB family members p50, p65 (relA), and c-Rel. Activation was dependent of tyrosine kinases but independent of PKC. , 1994a). , 1994a). OF SICNAL-TRANSDUCING-ASSOCIATED MOLECULES C. A NEW FAMILY Within the above mentioned studies, the direct link between the CD40 surface receptor and signal transduction has remained unresolved. , 1995) have identified, using the yeast two-hybrid system (Fields and Song, 1989), a protein which can directly associate with the cytoplasmic tail of CD40.

All these animals are mostly investigated for T-B cell responses. However, with the recent insight in the much broader expression of CD40, it will be of interest to further study these animals for other defects, especially during specific situations of infections and other disease states. , 1994). Apart from gene inactivation, several studies have investigated the in vivo role of CD40-CD40-L interactions by administration of either antiCD40-L (anti-gp39) or sCD40-Ig or by construction of sCD40-Ig transgenic mice.

Download PDF sample

Rated 4.14 of 5 – based on 10 votes