AID for Immunoglobulin Diversity by Frederick W. Alt

By Frederick W. Alt

Advances in Immunology, a protracted demonstrated and hugely revered serial, offers present advancements in addition to accomplished reports in immunology. Articles deal with the big variety of themes that include immunology, together with molecular and mobile activation mechanisms, phylogeny and molecular evolution, and medical modalities. Edited and authored via the key scientists within the box, every one quantity offers updated details and instructions for destiny learn.

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Ramiro, A. , McBride, K. , and Nussenzweig, M. C. (2003). C‐terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion. Mol. Cell 12, 501–508. , Schrum, J. , Manis, J. , and Alt, F. W. (2005). The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation. Nature 438, 508–511. Begum, N. , Boyer, L. , and Honjo, T. (2004a). Uracil DNA glycosylase activity is dispensable for immunoglobulin class switch. Science 305, 1160–1163.

And Scharff, M. D. (2002). Activation‐induced cytidine deaminase turns on somatic hypermutation in hybridomas. Nature 415, 802–806. , Lo, S. , Carruthers, C. , Plas, D. , Martin, S. , Geha, R. , Nahm, M. , and Chaplin, D. D. (1996). Affinity maturation without germinal centres in lymphotoxin‐a‐deficient mice. Nature 382, 426–462. McBride, K. , Ramiro, A. , and Nussenzweig, M. C. (2004). Somatic hypermutation is limited by CRM1‐dependent nuclear export of activation‐induced deaminase. J. Exp. Med.

Here we consider the function (and possible structure) of AID as a DNA deaminase in the context of the entire deaminase superfamily and, in particular, compare AID to the APOBEC3s, since they constitute the major grouping of DNA deaminases active in immunity. 2. , 2000). , 1993)], it was reasonably suggested that AID might also prove to be an RNA‐editing enzyme. , 2003), it subsequently became evident that AID itself acts directly on immunoglobulin gene DNA, diversifying antibodies by active mutation.

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