Applying Quantitative Bias Analysis to Epidemiologic Data by Timothy L. Lash

By Timothy L. Lash

This textual content offers the first-ever compilation of bias research equipment to be used with epidemiologic info. It courses the reader in the course of the making plans phases of bias research, together with the layout of validation reports and the gathering of validity facts from different assets. 3 chapters current equipment for corrections to handle choice bias, out of control confounding, and category blunders. next chapters expand those easy methods to multidimensional bias research, probabilistic bias research, and a number of bias research. The textual content concludes with a bankruptcy on presentation and interpretation of bias research results.

Although suggestions for bias research were to be had for many years, those equipment are thought of tough to enforce. this article not just gathers the equipment into one cohesive and arranged presentation, it additionally explains the equipment in a constant model and offers customizable spreadsheets to enforce the ideas. by way of downloading the spreadsheets (available at hyperlinks supplied within the text), readers can stick to the examples within the textual content after which adjust the spreadsheet to accomplish their very own bias analyses. Readers with out adventure utilizing quantitative bias research could be in a position to layout, enforce, and comprehend bias analyses that deal with the key threats to the validity of epidemiologic learn. more matured analysts will worth the compilation of bias research equipment and hyperlinks to software program instruments that facilitate their projects.

Timothy L. Lash is an affiliate Professor of Epidemiology and Matthew P. Fox is an Assistant Professor within the middle for foreign well-being and improvement, either on the Boston college tuition of Public well-being. Aliza okay. Fink is a undertaking supervisor at Macro overseas in Bethesda, Maryland. jointly they've got geared up and provided many day-long workshops at the equipment of quantitative bias research. additionally, they've got collaborated on many papers that constructed tools of quantitative bias research or used the tools within the facts research.

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Example text

Errors in classification arise in the study population, as an inherent part of the data collection and analysis, so should ordinarily be corrected first. Selection bias arises from differences between the study participants and the source population, so should ordinarily be corrected second. Confounding exists at the level of the source population, so error arising from an unmeasured confounder should ordinarily be analyzed last. While this order holds in general, exceptions may occur. For example, if internal validation data on classification errors are used to correct for information bias, and the internal validation data were collected after participants were selected into the study population, then one would correct first for classification error and then for selection bias.

The original 30 2 A Guide to Implementing Quantitative Bias Analysis analysis somewhat overestimated the protective effect and the conventional interval somewhat underestimated the total error, at least conditional on the accuracy of the distributions assigned to the bias parameters. Multiple Biases Modeling Multiple biases modeling is also an extension of simple bias analysis in which the analyst assigns probability distributions to the bias parameters, rather than single values or ranges, but now the analyst examines the impact of more than one bias at a time.

2 outlines the topics to consider while planning for quantitative bias analysis. These topics are further explained in the sections that follow. 3 can be applied to each bias. Consider the number bias analysis of biases to be analyzed, the interrelations between biases, the inferential question, and computational requirements Creating a Data Collection Plan for Bias Analysis As described in the preceding examples, planning for quantitative bias analysis during the study design will produce the most effective analyses.

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