Assessment of Risk from Low-Level Exposure to Radiation and by Avril D. Woodhead, Claire J. Shellabarger, Virginia Pond,

By Avril D. Woodhead, Claire J. Shellabarger, Virginia Pond, Alexander Hollaender (auth.), Avril D. Woodhead, Claire J. Shellabarger, Virginia Pond, Alexander Hollaender (eds.)

The current workshop had its orlglns in discussions between Alexander Hollaender, Oddvar Nygaard, Donald Borg, Richard Setlow and Victor Bond at the desire for a symposium that may take care of a extensive spectrum of urgent topics concerning the physics, chemistry, and organic activities of ionizing radiations, and the theoretical and functional difficulties of hazard evaluate. It quickly turned obvious that the spectrum of topics thought of used to be too huge for the specified intensity of assurance; in truth, it appeared un­ most likely that the convention contributors might have the history wisdom to span the gamut. for this reason, separate conferences have been determined upon, the 1st of which, comparability of Mechanisms of Carcinogenesis by way of Radiation and Chemical brokers, was once held on the nationwide Bureau of criteria, Gaithersburg on December 6-7, 1983. The assembly was once backed by way of the NCI. the second one assembly has emerged because the current workshop at Brookhaven nationwide Laboratory. An interface among the 2 meetings has been supplied via Michael Fry and Donald Borg, who've summarized the salient issues emanating from the NCI Symposium. We meant that the 1st convention should still specialise in the fundamental mechanisms of radiation and chemical carcinogenesis, whereas the second one, the current assembly, could emphasize exposure-response relationships, fairly the theoretical and useful comparable­ ities and variations among publicity to chemical cancer causing agents in comparison to publicity to ionizing radiation.

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Jhanwar, S. , Chaganti, R. S. , and Hayworth, W. , 1982, Two human c-onc genes are located on the long arm of chromosome 8, Proc. Natl. Acad. Sci. USA, 79:7842. Rowley, J. , 1980, Chromosome abnormalities in human leukemia, Ann. Rev. , 14:17. , 1982, Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells, Proc. Natl. Acad. Sci. USA, 79:7837. Promotion/Progression and Involvement of Non-DNA Targets - T. J. Slaga (No references submitted) Modifiers of Mutagenesis and Carcinogenesis - L.

43:2448s. , 1983, BowmanBirk soybean protease inhibitor as an anticarcinogen, Cancer Res. ), 43:2454s. COMMON MOLECULAR MECHANISMS 37 DISCUSSION Holtzman: Would you care to comment on evidence by Michael Gould and co-workers (Gould, 1984; Mulcahy et al, 1984) and evidence from "so-called" synergistic interactions in our laboratory, that initiation events are much more common then can be deter~ined from the results of carcinogenesis studies. Borg: What is the comparison? Holtzman: tumors. More lesions than you would see expressed as Borg: Yes.

1983, Inhibition of neoplasia by minor dietary constituents, Cancer Res. ), 43:2448s. , 1983, BowmanBirk soybean protease inhibitor as an anticarcinogen, Cancer Res. ), 43:2454s. COMMON MOLECULAR MECHANISMS 37 DISCUSSION Holtzman: Would you care to comment on evidence by Michael Gould and co-workers (Gould, 1984; Mulcahy et al, 1984) and evidence from "so-called" synergistic interactions in our laboratory, that initiation events are much more common then can be deter~ined from the results of carcinogenesis studies.

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