By Abul K. Abbas MBBS, Andrew H. H. Lichtman MD PhD, Shiv Pillai MBBS PhD
In this up-to-date variation of Basic Immunology, the authors proceed to bring a transparent, smooth creation to immunology, making this the most obvious selection for state-of-the-art busy scholars. Their event as academics, direction administrators, and teachers is helping them to distill the middle details required to appreciate this advanced box. by utilizing high-quality illustrations, relevant scientific instances, and concise, centred text, it is a completely accessible creation to the workings of the human immune process, with an emphasis on scientific relevance.
- Concise, clinically centred content is logically organized via mechanism for effective mastery of the material.
- Features an appendix of scientific cases and CD molecules.
- Includes numerous full-color illustrations, worthy tables, and chapter outlines.
- Focus questions within every one bankruptcy are perfect for self-assessment and review.
- Key points bolded during the textual content make it effortless to find very important information.
- Presents details in a structure and elegance that maximizes usefulness to scholars and teachers learning drugs, allied overall healthiness fields, and biology.
- Fully up-to-date content equips you with the most recent appropriate advances in immunology.
- Revised and updated artwork complements your visible studying of vital ideas and decreases the over the top real info present in greater textbooks.
- Twelve brand-new animations on hand on Student Consult support additional clarify complicated concepts.
- Student seek advice book model integrated with buy. This more desirable book event gives you entry to the textual content, figures, photographs, word list of immunology phrases, self-assessment questions, and references on quite a few units.
Read or Download Basic Immunology: Functions and Disorders of the Immune System, 5e PDF
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Additional info for Basic Immunology: Functions and Disorders of the Immune System, 5e
Neutrophils live for only a few hours in tissues, so they are the early responders, but they do not provide prolonged defense. • Monocytes are less abundant in the blood than neutrophils, numbering 500 to 1000 per µL (Fig. 2-7, B). They also ingest microbes in the blood and in tissues. During inflammatory reactions, monocytes enter extravascular tissues and differentiate into cells called macrophages, which, unlike neutrophils, survive in these sites for long periods. Thus, blood monocytes and tissue macrophages are two stages of the same cell lineage, which often is called the mononuclear phagocyte system (Fig.
In response to infections, the production of neutrophils from the bone marrow increases rapidly, and their number may rise to as high as 20,000 per µL of blood. The production of neutrophils is stimulated by cytokines, known as colony-stimulating factors (CSFs), which are secreted by many cell types in response to infections and act on hematopoietic stem cells to stimulate proliferation and maturation of neutrophil precursors. 36 A CHAPTER 2 Innate Immunity B FIGURE 2-7 Morphology of neutrophils and monocytes.
When this happens, the NK cell inhibitory receptors are not engaged, and if the virus induces expression of activating ligands at the same time, the NK cells become activated and eliminate the virus-infected cells. The role of NK cells and CTLs in defense illustrates how hosts and microbes are engaged in a constant struggle for survival. The host uses CTLs to recognize MHC-displayed viral antigens, viruses inhibit MHC expression to evade killing of the infected cells by CTLs, and NK cells can compensate for the defective CTL response because the NK cells are more effective in the absence of MHC molecules.