Biological Systems Engineering by Mark R. Marten, Tai Hyun Park, and Teruyuki Nagamune (Eds.)

By Mark R. Marten, Tai Hyun Park, and Teruyuki Nagamune (Eds.)

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Greg. Stephanopoulos and George Stephanopoulos, Computer-Aided Synthesis of Biochemical Pathways, Biotechnol. , 36, 1119-1132 (1990). , Flux Analysis and Control of the Central Metabolic Pathways in Escherichia coli, F E M S Microbial. , 19, 85-116(1996). , J. Biosci. , 87, 666-677 (1999). Ferment. ,86 (3) 284-289 (1998). [51]Yonehara, T. and R. Miyata, Fermentation Production of Pyruvate from Glucose by Torulopsis glabrata, J. Ferment. , 78, 155-159 (1994). [52]Miyata, R. Yonehara, Improvement of Fermentative Production of Pyruvate from Glucose by Torulopsis glabrata IFO 0005, J.

Rapoport, A Linear Steady-state Treatment of Enzymatic Chains. General Properties, Control and Effector Strength, Eur. J. , 42, 89- 95(1974). C. and J. Delgado, Flux Calculation Using Metabolic Control Constraints, Biotechnol. , 14, 554-560 (1998). [60]Ehlde, M. and G. Zacchi, A general formalism for Metabolic Control Analysis, Chem. Eng. , 52, 2599-2606 (1997). [61]Kacser, H . Sauro,and L. Acerenza, Enzyme-Enzyme Interactions and Control Analysis. 1. The case of Non-Additivity: Monomer-Oligomer Associations, Eur.

W. Appl. Biochem. Biotechnol. 1998, 70-72, 187-198. 20. ; Millard, C. ; Champion, K . ; Clark, D. ; Donnelly, M . I. Appl. Environ. Microbiol. 2001, 67, 148-154. 21. Hong, S. ; Lee, S. Y. J. Microbiol. Biotechnol. 2000, 10(4), 496-501. ; ACS Symposium Series; American Chemical Society: Washington, DC, 2002. ch004 Metabolic Control Analysis in Glutamate Synthetic Pathway: Experimental Sensitivity Analysis at a Key Branch Point Hiroshi Shimizu, Hisaya Tanaka, Akinori Nakato, Keisuke Nagahisa, and Suteaki Shioya* Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita Osaka 565-0871 Japan Experimental method for metabolic control analysis (MCA) was applied to investigation of a metabolic network of glutamate production by Corynebacterium glutamicum.

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