Cellular Signaling and Innate Immune Responses to RNA Virus by Allan R. Brasier, Adolfo García-Sastre, Stanley M. Lemon

By Allan R. Brasier, Adolfo García-Sastre, Stanley M. Lemon

A finished survey of the newest discoveries during this field.

  • Provides a platform of information that may bring about the advance of more suitable tools for controlling the unfold of RNA viruses or editing their ailment course.
  • Synthesizes contemporary findings during this fast-moving box whereas additionally reviewing approved wisdom.
  • Focuses at the antiviral signaling pathways within the host, together with particular development acceptance receptors and the way those mobile alarms sign the innate immune reaction.
  • Examines the ways that particular significant RNA virus households have interaction with, turn on, and elude those signaling pathways and responses.

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Takaoka, C. Taya, and T. Taniguchi. 2005. Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction. Nature 434:1035–1040. 43. , H. Yanai, H. Negishi, M. Asagiri, M. Sato, T. Mizutani, N. Shimada, Y. Ohba, A. Takaoka, N. Yoshida, and T. Taniguchi. 2005. IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature 434:772–777. 44. , J. Ellegast, S. Kim, K. Brzozka, A. Jung, H. Kato, H. Poeck, S. Akira, K. K. Conzelmann, M. Schlee, S. Endres, and G.

Du, L. Shamel, S. Sovath, S. Mudd, M. Huber, C. Kalis, S. Keck, C. Galanos, M. Freudenberg, and B. Beutler. 2005. CD14 is required for MyD88independent LPS signaling. Nat. Immunol. 6:565–570. 47. , T. W. Mak, G. Sen, and X. Li. 2004. Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta. Proc. Natl. Acad. Sci. USA 101: 3533–3538. 48. Jude, B. , Y. Pobezinskaya, J. Bishop, S. Parke, R. M. Medzhitov, A. V. Chervonsky, and T.

Innate cellular response to virus particle entry requires IRF3 but not virus replication. J. Virol. 78:1706–1717. 13. , C. Wang, E. Spencer, L. Yang, A. Braun, J. You, C. Slaughter, C. Pickart, and Z. J. Chen. 2000. Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell 103:351–361. 14. Diebold, S. , T. Kaisho, H. Hemmi, S. Akira, and C. Reis e Sousa. 2004. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA.

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