By W. Bannwarth, B. Hinzen
The recent version of this practice-oriented guide positive factors completely up to date contents, together with contemporary advancements in parallel synthesis.
A new bankruptcy on screening enhances the evaluate of combinatorial procedure and artificial methods.
"Experimental information and whole response facts [...] are a relentless subject operating via this work"
"Recommended to beginners within the box of combinatorial chemical synthesis as a result of its huge scope"
(Journal of the yankee Chemical Society)
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Functional Group of Scavenger Resin Application as Scavenger for primary amine electrophiles: acid chlorides, acid anhydrides, chloroformates, sulfonyl chlorides, isocyanates tertiary amine protons, acids isocyanate isothiocyanate nucleophiles: amines, hydrazines, anilines, thiols, alkoxides, organometallic reagents benzaldehyde nucleophiles: hydrazines, hydroxylamines, organometallic reagents thiol alkylating agents: halides, mesylates, tosylates, 1,2-unsaturated carbonyl compounds thiourea alkylating agents: halides, mesylates, tosylates hydrazinosulfonylphenyl electrophiles: aldehydes, ketones N,N-diethanolamino boronic acids hydrazine, and to trap HCl and acid impurities, respectively.
The linker is versatile in that it can be used not only for the attachment of amines but also for the attachment of carboxylic acids and alcohols. Primary amines attached to the solid support via an oxime carbamate have been used for the preparation of diverse ureas of type 25 according to Scheme 10. In this respect, further diversity could be introduced, concomitant with release from the support . 4 Benzyl-Linked Approaches for Secondary Amines An elegant approach for the preparation of secondary amines is outlined in Scheme 11.