By Michael T. Lotze, Angus W. Thomson
Dendritic cells by means of Lotze & Thompson is well-researched booklet for lecturers and scholars drawn to scientific study. This e-book eventually places the complete sector of Dendritic Cells study below one disguise. All chapters are necessary and distinct. in spite of the fact that, the booklet lacks fresh guides (1998-2000) on Dendritic Cells.
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Ghali Hassan college of wellbeing and fitness technological know-how college of Tasmania
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Extra resources for Dendritic Cells, Second Edition: Biology and Clinical Applications
1999). Previously it was shown that human thymic cells resembling DCs express CD4 and are negative for CD8α. , 1999). , 1999). , 1999). The CD1aϪCD4ϩ cells express high levels of CD123 (IL-3Rα). In the presence of IL-3 or IL-3 and CD40L they differentiate into cells with dendritic extensions that express high levels of HLA-DR and CD54 (ICAM-1). Moreover, the cells acquire CD80 and CD83 and upregulate CD86 upon culture in IL-3 plus CD40L. The CD1aϪCD3ϪCD4ϩ thymocytes are therefore DC precursors (pDC).
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To examine the function of DC1s and DC2s in T helper cell differentiation, CD4ϩCD45ROϪCD45RAϩ naïve T cells were cultured for 6 days with: (1) 24-hour CD40Lactivated DC1s; (2) 24-hour CD40L-activated DC2s or (3) anti-CD3 and anti-CD28 coated on a culture plate. After 6 days of priming, T cells were re-stimulated with anti-CD3 and anti-CD28 coated on a culture plate for either 5 hours to examine intracellular cytokine expression using flow cytometry or 24 hours to examine cytokines secreted into the culture supernatants using ELISA.